The risk of developing a second cancer after receiving craniospinal proton irradiation.

نویسندگان

  • Wayne D Newhauser
  • Jonas D Fontenot
  • Anita Mahajan
  • David Kornguth
  • Marilyn Stovall
  • Yuanshui Zheng
  • Phillip J Taddei
  • Dragan Mirkovic
  • Radhe Mohan
  • James D Cox
  • Shiao Woo
چکیده

The purpose of this work was to compare the risk of developing a second cancer after craniospinal irradiation using photon versus proton radiotherapy by means of simulation studies designed to account for the effects of neutron exposures. Craniospinal irradiation of a male phantom was calculated for passively-scattered and scanned-beam proton treatment units. Organ doses were estimated from treatment plans; for the proton treatments, the amount of stray radiation was calculated separately using the Monte Carlo method. The organ doses were converted to risk of cancer incidence using a standard formalism developed for radiation protection purposes. The total lifetime risk of second cancer due exclusively to stray radiation was 1.5% for the passively scattered treatment versus 0.8% for the scanned proton beam treatment. Taking into account the therapeutic and stray radiation fields, the risk of second cancer from intensity-modulated radiation therapy and conventional radiotherapy photon treatments were 7 and 12 times higher than the risk associated with scanned-beam proton therapy, respectively, and 6 and 11 times higher than with passively scattered proton therapy, respectively. Simulations revealed that both passively scattered and scanned-beam proton therapies confer significantly lower risks of second cancers than 6 MV conventional and intensity-modulated photon therapies.

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عنوان ژورنال:
  • Physics in medicine and biology

دوره 54 8  شماره 

صفحات  -

تاریخ انتشار 2009